Therapeutic Combinations against Melanoma Brain Metastases

Sixue Liu, PhD

Mentor Roger Lo, MD, PhD
Award Type Career Development Award
Institution University of California, Los Angeles

Melanoma is a lethal form of skin cancer because it has a high propensity to metastasize, especially to the brain (often causing death). Compounding this problem is the observation that melanoma brain metastasis is relatively therapy resistant. We proposed a novel sequential-combinatorial therapy aimed at suppressing melanoma brain metastasis and designed studies (using novel molecular technologies) to understand the underlying mechanisms in order to accelerate clinical translation of our findings.