Therapeutic Combinations against Melanoma Brain Metastases
Sixue Liu, PhD
Mentor | Roger Lo, MD, PhD |
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Award Type | Career Development Award |
Institution | University of California, Los Angeles |
Melanoma is a lethal form of skin cancer because it has a high propensity to metastasize, especially to the brain (often causing death). Compounding this problem is the observation that melanoma brain metastasis is relatively therapy resistant. We proposed a novel sequential-combinatorial therapy aimed at suppressing melanoma brain metastasis and designed studies (using novel molecular technologies) to understand the underlying mechanisms in order to accelerate clinical translation of our findings.