Therapeutic Combinations against Melanoma Brain Metastases
Sixue Liu, PhD
|Mentor||Roger Lo, MD, PhD|
|Award Type||Career Development Award|
|Institution||University of California, Los Angeles|
Melanoma is a lethal form of skin cancer because it has a high propensity to metastasize, especially to the brain (often causing death). Compounding this problem is the observation that melanoma brain metastasis is relatively therapy resistant. We proposed a novel sequential-combinatorial therapy aimed at suppressing melanoma brain metastasis and designed studies (using novel molecular technologies) to understand the underlying mechanisms in order to accelerate clinical translation of our findings.