Mechanisms Underlying Effectiveness of PI3Kd-Inhibited T Cells for Adoptive Cell Transfer Therapy
Guillermo Omar Rangel Rivera
|Mentor||Chrystal M. Paulos, PhD|
|Award Type||Medical Student Award|
|Institution||Medical University of South Carolina|
|Donor Support||In honor of Christopher Westdyk|
Findings from this grant will shed light on 1) how stemness is sustained by modulating PI3Kδ signaling in T cells using FDA-approved drugs and 2) how transcription regulation in T cell mitochondria contributes to tumor immunity.