Mechanisms Underlying Effectiveness of PI3Kd-Inhibited T Cells for Adoptive Cell Transfer Therapy
Guillermo Omar Rangel Rivera
| Mentor | Chrystal M. Paulos, PhD |
|---|---|
| Award Type | Medical Student Award |
| Institution | Medical University of South Carolina |
| Donor Support | In honor of Christopher Westdyk |
Description:
Findings from this grant will shed light on 1) how stemness is sustained by modulating PI3Kδ signaling in T cells using FDA-approved drugs and 2) how transcription regulation in T cell mitochondria contributes to tumor immunity.