Therapies that inhibit epigenetic modulators can induce a state of “virus mimicry” in cancer cells by activating long-overlooked “junk DNA” of the human genome. Thi...

A major obstacle to even the best melanoma therapies is that in the majority of cases, the tumor never completely goes away. Even if a little bit remains, called the minima...

Melanomas arise from pigmented cells called melanocytes, typically in the skin. Melanomas can spread to distal parts of the body, through a process called metastasis. Metas...

Melanoma is the third most common malignancy to metastasize to the brain. It is estimated that at least 50% of patients with stage IV melanoma will develop brain metastases...

Metastasis is the main cause of melanoma death. Current treatments mostly fail to cure metastasis. It is of common knowledge that disseminated cancer cells (DCCs)...

Cancer immunotherapy (CI) drugs activate our own immune system to directly kill cancer cells. These drugs have revolutionized how we treat many cancers including melanoma....

Career Development Award – Claudia Capparelli, PhD

Description: The goal of this research is to target KDM5s family proteins to enhance the response to immune checkpoint inhibition in melanoma. The recently developed immune...

There has been great progress in increasing the treatment options for patients who have the skin cancer melanoma in the past decade. However, the melanoma will mo...

The cancer genomics field has focused on how mutations in the genome change proteins to cause cells to progress into metastatic cancers. However, new molecular profiling te...