Melanoma, a deadly form of skin cancer, often becomes resistant to current treatments, particularly immunotherapy. Although melanoma tumors contain many genetic mutations, ...

The treatment of melanoma with checkpoint inhibitor (CPI) therapy has produced rapid and substantial gains in survival, and as a result, the indications for its use have st...

Description: Immunotherapy has been shown to be effective in treating melanoma, even at an early stage of disease. Patients with Stage II melanoma are now able to receive a...

Traditional cancer therapy involves surgery, radiotherapy, and chemotherapy. These modalities aim to ablate the tumor, yet generally the disease relapses due to the ineffic...

Patients with lymph-node positive melanoma have a high risk of recurrence despite curative surgery. While adjuvant therapy given after surgery improves RFS and OS, ~25% of ...

The Hippo pathway in cancer, mediated by YAP1, has been implicated in therapy resistance and aggressive tumor behavior in melanomas treated with targeted therapies. However...

Immune therapies termed “immune checkpoint inhibitors” remove key “brakes” on immune cells. These treatments lead to long-term responses and cures in some patients ...

Description: Immunotherapies, such as CTLA-4 or PD-1 inhibitors, have revolutionized the treatment of metastatic melanoma patients. However, a key challenge to optimize the...