Genetic Drivers of Cutaneous Melanoma: Racial Disparities in Mutations

Melanoma, a serious type of skin cancer, affects people differently based on their racial background. Non-Caucasian groups, such as Black, Asian, and Hispanic individuals, often face more barriers to early diagnosis and treatment, leading to worse outcomes. This research seeks to explore how genetic differences across racial groups might influence melanoma’s development, particularly focusing on common gene mutations known to drive this cancer. The study will analyze data from 470 melanoma cases in The Cancer Genome Atlas Program (TCGA) to see if specific gene mutations are linked to genetic differences in certain racial groups. The goal is to understand if certain populations are more likely to develop melanoma due to unique genetic factors. This analysis will look at mutations in key genes, like BRAF, NRAS, and NF1, which help melanoma grow and spread by activating pathways that increase cell survival and division. We will also explore how ultraviolet (UV) radiation and other factors contribute to melanoma’s high mutation rates. By identifying genetic patterns tied to specific racial groups, this study could pave the way for more personalized approaches to melanoma prevention and treatment, helping doctors provide better care for diverse populations and addressing existing health disparities.