Elena Ezhkova’s Abstract Melanoma is an aggressive type of skin cancer with a low survival rate when it metastasizes. Melanoma originates mainly in sun-exposed areas,...

Kazuko Nishikura’s Abstract The phenomenon of “RNA editing” is a relatively recent discovery with exciting implications. RNA editing is a process that modifies th...

Current immunotherapies have dramatically improved clinical outcomes, but more than half of metastatic melanoma patients have poor responses and primary resistance. With ti...

Brain metastases remain a leading cause of death in patients with metastatic melanoma. One of the most exciting advances in the treatment of CNS metastases was combined che...

Immunotherapy has been remarkably successful in the treatment of melanoma, but not all patients benefit from therapy and its effects is in most cases temporary, followed by...

Our immune system operates on a balance of cells that that can destroy infected or cancerous tissue with those that prevent attacking healthy tissue. This equilibrium is af...

While immunotherapy has revolutionized the management of advanced melanoma, many patients still do not benefit from this treatment strategy. Indeed, currently available imm...

Cancer treatment was revolutionized when scientists discovered how to activate a patients’ own immune system to fight tumors. Unfortunately, some patients have tumors tha...

Melanoma is the most lethal skin cancer and when detected at an advanced stage in which cells have spread throughout the body (known as metastasis), success of currently av...

Over the past decade, harnessing the power of a patient’s own immune system for the treatment of cancer has been a major medical breakthrough. By using drugs to block inh...

The majority of cancer patients do not yet benefit from immunotherapy, including from immune checkpoint therapies that invigorate the patients’ own immune systems to figh...

Melanoma is one of the fastest growing malignancies and accounts for 5.5% of all new cancer cases in the United States. Treatment options and prognosis of melanoma patients...