Therapeutic Combinations against Melanoma Brain Metastases

Sixue Liu, PhD
Roger Lo, MD, PhD
Career Development Award
University of California, Los Angeles
Melanoma is a lethal form of skin cancer because it has a high propensity to metastasize, especially to the brain (often causing death). Compounding this problem is the observation that melanoma brain metastasis is relatively therapy resistant. We proposed a novel sequential-combinatorial therapy aimed at suppressing melanoma brain metastasis and designed studies (using novel molecular technologies) to understand the underlying mechanisms in order to accelerate clinical translation of our findings.