Mechanisms Underlying Effectiveness of PI3Kd-Inhibited T Cells for Adoptive Cell Transfer Therapy

Guillermo Omar Rangel Rivera
Chrystal M. Paulos, PhD
Medical Student Award
Medical University of South Carolina
In honor of Christopher Westdyk
Description:
Findings from this grant will shed light on 1) how stemness is sustained by modulating PI3Kδ signaling in T cells using FDA-approved drugs and 2) how transcription regulation in T cell mitochondria contributes to tumor immunity.