Harnessing Resveratrol Mediated Upregulation of MHC-I to Potentiate Melanoma Immunotherapy

Description:

While immunotherapy treatment has radically improved the outcomes of patients with advanced melanoma, around half of patients have no response. This is in part because of cancer cells’ altering of themselves so that they cannot be identified and eliminated by immune cells. The long-term goal of this project is to determine how the natural compound resveratrol undoes this alteration so that cancer cells can be recognized and eliminated by the body’s immune system.