My wife has had recent disease progression accompanied by LDH (lactate dehydrogenase) levels spiking over 1,000. Are there any meds/therapies to bring LDH down to help w/ tumor suppression? Our main oncologist says "no" despite there being some good papers from the last 5-10 yrs on meds that can reduce LDH in the lab. Some natural supplements that might reduce LDH include Green Tea Extract, Xi Jue Teng (spatholobus suberectus) and Gossypol (cottonseed oil). We are trying the first 2. We also have some Hydroxychloroquine (HCQ) which was going to be used with TMZ about 6 months ago, but it was decided to skip that in favor of another targeted therapy. HCQ has been in some clinical trials as a good tumor suppression agent, works as an Anti-Autophagy agent to suppress tumor growth. I can't convince my wife to just start trying HCQ to see if it helps. Any experience or advice with this? Seems like some docs at Univ of Penn are big fans of using HCQ with cancer/melanoma.