Amanda has been on all of the "protocol" treatments. She has done really well on the Cotellic and Zelboraf combo, until now. Multiple tumors in the lungs and almost double in size since September. We see the Dr Monday for the "plan". Possible trial.. I am trying to stay positive, while my daughter feels that she is starting these next months as the end. She also has a new pleural thickening. I can't make sense of that.