Good news. After being diagnosed stage 4 10 weeks ago roughly with over 100 liver lesions and lung Mets, I just got new scan results.
I had been taking Mektovi/Braftovi for about 3 weeks total on and off during the 10 weeks due to high liver enzymes ( side effect of meds). When I didn't take the braf drugs I would take high doses of steroids to get enzymes down than restart. I also took tafinlar and mek for about 5 days but still same liver reaction. Despite theses hurdles which Dr Weber easily handled, all tumors decreased roughly 50% and some completely dissapeared. That's miraculous in my book and the best Christmas gift I could have hoped for. I figure I am halfway to where I want to be which is tumor free.
Plan is to stay on the Braf drugs for about 4 months and hopefully my liver enzymes will eventually cooperate than switch to the IPI/NIVO combo. Since I have become an autodidact in the field of melanoma (lol) that seems to be the route with best chance of durable response. If that doesn't work I could always go back to braf drugs.
I can't thank everyone on this site enough for sharing their stories. It's been immensely inspiring hearing people's struggles with this insidious disease and I wish you all Happy Holidays!