I have been on Opdivo every other week for almost 6 months. I have had very few symptoms...fatigue mostly. The first month I was on it I had a horrible bout of reflux and he changed my meds from an over the counter to pantoprazole 40mg that is time release. After that change no more major reflux issue. I have notice the last month or so that my throat/back of my tonged is irritated. I am wondering if this can be a reaction of the opdivo to possible inflammation in the throat area......or maybe some other reaction. It has not gotten any worse but also not getting any better. Of course I will talk to the doc next time I am in the office but wondering if anyone else has had any type of throat issue while on treatment.