So after almost of a year of Opdivo and positive results I had one stubborn met show up on the iliac (upper part of hip bone). I then had 5 rounds of radiation and waited the 6-8 weeks to find out that the radiation didn't help and the met has doubled in size since late Dec. My doctor is recommending opdivo + yervoy. I have done very well on opdivo with minimal side effects. I am hoping for minimal side effects with the new treatment but know the reality is that the chance of side effect are much higher. My CT scans stated Continued increase in size of metastasis with extraosseous necrotic tumor now 4.6 cm x 4.4cm previously 2.9cm x 1.6cm. Wondering about the statement "extraosseous necrotic"?? Thanks for any insight!