This is my first post here, however in the past few weeks I have visited quite frequently to learn from all of your helpful posts and comments!
I am currently considering participating in the Keynote 716 trial, which is testing the effectiveness of treating stage 2B/2C patients with Pembrolizumab(Keytruda) adjuvant therapy. I haven’t seen much on here about this trial so I wanted to see if there are others out there considering this for their “high risk” stage 2 melanoma. Some background on me is below. I also would love any input from those of you who have been treated with Pembrolizumab in terms of side effects and things like that. I welcome any of your opinions! Thank you :-)
About a month ago I was diagnosed with superficial spreading Melanoma on my back, biopsy revealed it was Breslow thickness of 3.2mm with ulceration, making it stage 2B. WLE had clear margins and SLNB came back negative, confirming the stage 2B diagnosis. I also had the decisiondx castle testing done which classified it as class 2B, the highest risk of recurrence (50% chance of recurrence within 5 years). I am 26 years old so I am also trying to weigh the infertility risks of the adjuvant treatment since there is not much data on those risks yet.
More about the trial.. 50% of patients will receive Pembrolizumab and 50% will receive a placebo. It is a double blind study so neither doctor nor patient will know if they are receiving the drug or placebo. Treatment will be about every 3 weeks for a year.