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# of Infusions for Stage 3 Opdivo

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# of Infusions for Stage 3 Opdivo

Posted By
Steve33
10/14/2020 10:10am
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Replies: 6

Hi All,

Minor question regarding # of adjuvant Opdivo infusions for Stage 3 folks. I recently moved a crossed the country. My previous oncologist overseeing my Opdivo infusions recommended 13 infusions every 4 weeks to cover the full 52 week year. My new oncologist recommended 12 infusions every 4 weeks, but is ok with doing 13 if I prefer. The general feedback is it really shouldn’t make a difference and that benefits of immunotherapy don’t stop after the last infusion.

It’s approved by insurance for 13 and adverse effects have been minor so far, so I’m leaning towards just getting the 13th infusion. I‘ve always approached my melanoma as attacking it aggressively as much as possible in my treatment.

What have other Stage 3 people done? 12 or 13 infusions?

Stage 3B, Parotid Gland/ CLND, Opdivo

I had 12, but to me 13 would make it a full year. I’m thinking I should have questioned it and asked for a 13th infusion but I’m not sure if it would make that big of a difference either way.

i think dosage important in this discussion. i was prescribed 240 mg twice a month for a year. 24x total.

Anonymous - (10/15/2020 - 8:54pm)

Opdivo infusions are either 240 mg every 2 weeks or 480 mg every 4 weeks. So if the docs are discussing monthly infusions they are talking about 480mg every 4 weeks.

This a link to the FDA prescribing information - https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/125554s070lbl.pdf - It gives the following prescribing information:

Administer OPDIVO as an intravenous infusion over 30 minutes.
 Unresectable or metastatic melanoma
 OPDIVO 240 mg every 2 weeks or 480 mg every 4 weeks.
 OPDIVO 1 mg/kg, followed by ipilimumab on the same day, every
3 weeks for 4 doses, then OPDIVO 240 mg every 2 weeks or 480 mg
every 4 weeks.
 Adjuvant treatment of melanoma
 OPDIVO 240 mg every 2 weeks or 480 mg every 4 weeks.

2x a month is very disruptive to one's life.

. On the other hand i got an attendance award at my infusion clinic and am often mistaken for an employee.

mine is via a port which involves both surgery to install and remove. The only explanation i got regarding port is a vague reference to vein collapse.

so if 480 mg once a month intravenous works as well as 2x a month thru a port, the former is much better .

Mu husband also has recurrence and is now Stage 3. He will be doing his first Opdivo treatment October 6th. Once a month for 12 months is the Schedule his oncologist has given him. He also has had 21 radiation treatments and finished that two weeks ago.

Karen

They are also putting a Port in even though he will be getting the monthly treatments. The Doc says he doesn't have good veins and the Port was recommended in his case.

Karen