My mother was diagnosed with melanoma in rectum which was operated and removed. After surgery she was undergoing immunotherapy by Nivolumab. After 7th dose, non resectable melanoma was detected in lungs and bones with symptom of pleural effusion. She has been given first dose of Ipilimumab along with Nivolumab. After 2 weeks she had fever which doctors suspected to be viral fever and was given antibiotics like amikacin. Blood tests for bacterial infection were negative. Now it has been a week, she is still having fever. Her body temperature increases to around 101 and starts decreasing by itself. She is having such cycles quite frequently now along with severe cough when her body temperature is elevated.