Hello, I have written on here a few times, was diagnosed with stage 4 metastatic melanoma on Dec 17, 2018, after 1 year of Opdivo and NED, then bam, here I am again, multiple lesions on liver and lungs and the few lymph nodes they left after the original surgeries. Started the Opdivo/Yervoy treatment on 1/22 and go back for my 2nd treatment on 2/11. I have been so very tired, no energy, severe back aches, severe headaches and just feeling down. My husband is very supportive, we are eating clean, trying to do everything to combat what we can on our side. I made an appointment with a counselor that will be next week, but all in all just want to feel normal, like I can do a day without hurting ar being exhausted. Is this normal? I also speak with my Dr tomorrow, but dammmm. Does this get better?