Nice interview of Dr. Allison and his work in discovering Ipi and his on going research at MD Anderson! https://www.quantamagazine.org/nobel-laureate-james-p-allison-cures-canc...
Thanks for this post, Ed! I'm being treated at MD Anderson and it was great to get an insight on an amazing doctor there. I really thought I was going to die - that this melanoma was going to take me out... after four ipi/nivo infusions, I don't feel that way any more. Scans on 2/15 and am excited as can be. Fingers crossed.
Primary 1B in 2014 - WLE and SNB negative.
Recurrence Dec 2019 - Stage IV with mets in liver and lungs. Currently on ipi/nivo combo @ MD Anderson (Houston, TX).
Great article about Dr. James Allison. Thank you very much Ed. In 2012, I had melanoma in my brain, both lungs, liver, kidney, gall bladder, left adrenal gland and spinal cord.
I received two brain surgeries plus Gamma Knife followed up with the very first clinical trial of Yervoy and Opdivo. Six and a half years later, all is well, still no cancer.
Jennifer, best wishes to you, everything is going to be all right.
John J Kissane
Thanks for sharing, Ed!!! OMG!!!!:
From the article - per Allison ~ "The big pharmaceutical companies are now all players. Many, many early biotech firms are also trying to gain a presence. What you see, though, is that a lot of companies with patents on older, more conventional drugs are experimenting by combining them with checkpoints, just because they have the drugs. This is being done, in my opinion, without a lot of thought. A lot of them fail, but that information is usually lost because there’s no requirement for reporting. That’s still important information. So many combinations that are being tried are duplicative. It’s just a mess."
Interviewer ~ "Are these trials being done on actual cancer patients?"
Allison ~ "Oh, yeah. They’re wasting patients. By that, I don’t just mean a large number of patients are not getting the treatments most likely to provide them benefit. Because we have a limited pool of patients, the most promising trials are not accruing sufficient patients fast enough to get these drugs to the clinic as quickly as we can."
Interviewer ~ "Is that ethical?"
Allison ~ "I think it’s unethical. I think there shouldn’t be any trial where you don’t learn something."
THAT!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! Is what I've been YELLING!!!!! Maybe folks will listen to HIM!!!!!!!!!!!!!!!!!!!!!!! Way to go Jennifer and John! Ratties Rock! - les
That's a very well done article. I've still haven't watched the Documentary on him. One of these days I will. Thanks for the post.
This is my hero, my rock star. Simply put, thank you Dr. James Allison for your dedicated research - it saved my life.
Stage IV in Aug 2005, cancer free since Jan 2009 thanks to the 5 doses of Ipi I received in the MDX-010 trial only after having exhausted all then standard care options.
There are no words.....
Every hour one American dies from melanoma.
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