So I have been reading for a while and finally decided to post. I was diagnosed as Stage 4 back at the end of August and started the combo at that time. The initial scans at that time showed only my liver was involved. Now, 8 weeks later, I did another set of scans, my liver is worse and it also is in my lungs. Everything just seems to be going in the wrong direction so quickly. I was wondering how long it took others to start seeing some positive results on the combo. Plus I'm not a candidate for the targeted therapies, so there is even more pressure on the combo working for me.