I'm reaching out for some suggestions (or maybe encouragement) regarding managing the side effects of Dabrafenib (Tafinlar) + Trametinib (Mekinist). I have been on this targeted therapy for over 2.5 years and it has worked well to manage the metatises to the lymph nodes in my neck, chest and axila. For that I am thankful. Unfortuately, I have very much struggled with side effects that include nausea, vomiting, diarrhea, lack of appetite, chills, night sweats, heart failure and so on. I have taken breaks from treatment which have helped to restore my strength, malnutrition, etc. After being hospitalized for congestive heart failure in December 2019, I was put on 1/4 dose of Tafinlar and the Mekinist was eliminated. I will stay off the Mekinist until I have an echocardiogram that is within normal limits. I'm finding that even on the 1/4 dose of Tafinlar, I struggle with nausea, chills, night sweats and have devloped several wart like growths on my skin.
I am getting very discouraged and am having thoughts of giving up on treatment completely. Anyone out there have similar side effects? If so, how are you managing?
Thank you in advance for your responses.