Those who have been following my posts can relate but I will give a summary again
Mom diagnosed with Vaginal melanoma Oct 2018 with metastsis to lymph nodes.
Surgery done to remove vaginal tumor.
Started Opdivo/Nivo Feb 6 ,2019 , Stable scans in May
August scans reveal two 1x1 cm lesions in liver
Sept 2019 started Ipi and Nivo combo.
Nov 2019 3rd dose of ipi/nivo
Severe colitis and hospitalization
dec 2019 scans again show tumor growth to 4 cm and more new lesions in liver
Jan 2019 , PET CT shows tumor grown to 7 cm
Melanoma doc at UCSF proposed trial Xmab20717 ( basically ipi/nivo with a different delivery way)
Radiation oncologist offered Y90 radio embolisation to liver
CPMC Melanoma doc is proposing another Trial https://clinicaltrials.gov/ct2/show/NCT03925350 basically a trial for Niraparib ( never heard of it before )
Now ..the real dilemma
Melanoma doc at UCSF wants to giver her ipi/nivo again with Y90 to see if it helps. ( Ipi/nivo gave her colitis and actually we saw disease progression after that )
Melanoma doc at CPMC wants to try the Niraparib as she hs a ATR mutation and Niraparib seemed to be promising for this mutation in Ovarian cancer patients and is more targeted.
As I have not heard of anybody on this board talking any of these. I am updating as well as seeking advice on what you feel should be a reasonable choice here.