Back here to seek help from you all. I posted in Jan for my mom diagnosed in Oct 2018. failed nivo, pi/nivo with mets to liver, lungs and vaginal area. She started on a trial of PARP inhibitor niraparib in feb , we thought her liver lesion was shrinking ( as the scan said there is less activity in the middle of tumor and it looks necrotic ) another scan in June released shows lesions back in the vaginal wall. She is kicked out of the trial for progression so we are back to choosing another trial out of two options provided. One being the XmAb20717 which as I understand is ipi/nivo ( I am concerned why she is being offered the same thing when we have only seen progression on it before. ) Can it do any good when ipi/nivo caused a significant progression in the liver ?
the second option is injecting a herpes virus into the vaginal lesions biweekly and scan after 12 weeks , i asked the onco will it help with the lesions in the lungs and liver and the reply is theoretically it should.
Please pour in your opinions and thoughts. I know ultimately we have to make a decision but would like to know what would you choose if you were faced with these two options.
I am really concerned with mom feeling very fatigued and low on energy.