I haven't posted for a few months. I was in hospital with raised ALT levels but felt fine.
After infusion number 3 of the ipi/nivo combo on April 2nd, my ALT crept up to 748 so they put me on Prednisone and even Mycelophate Mofetil. My ALT is now at 75 and slowly coming down. I am on 35mg of Prednisone only which the doctor is cutting by 5mg per week.
I have been fortunate and achieved very good reduction in the lung and liver tumors. The 20mm and 15mm tumors in both lungs are not visible on the latest CT. The liver is nearly there too. I want to go onto Opdivo alone and give myself the best possible chances.
The doctor said because the ALT went up so high, he doesn't want to give me Opdivo as he said the risk is too great.—I could die or suffer liver failure. He also said that because I have had very good response, it is not necessary at this stage to administer Opdivo as the combo is still providing reduction. He wants to monitor with regular three-monthly CT scans and go from there.
I am in Japan where the doctors are overly cautious and very careful.
Is this normal to not be refused Opdivo due to ALT going up so high?
Thank you in advance,