Just a quick follow up. Round 22 of Pembro complete and latest scans reveal that at 9 months I'm still NED! My medical oncologist even offered to let me consider if I want to stop the Pembro at this point citing a lack of data on efficacy between 1 year and 2 years of Pembro. She offered this because of the continuing joint pain that has finally caught up with me...at least for now, I said we will Warrior On!
Bubbles and Ed, I know you have weighed on this before but I could use your opinion on this. I am still tolerating the Pembro without any deviation in labs (all remarkably still in the normal range). It is kicking my rear a little in terms of joint pain and mobility (but it doesn't keep me from doing what I need to do like work, get things done around the house, etc). My thoughts are that as long as I can tolerate it Im going to keep going and see if I can hit the full 2 years of treatment unless there is reason not to. I can deal with the aches and pains, my bigger concern is that at some point it starts to do organ damage or some other issue is caused by the Pembro. Hopefully the labs will give me some advance warning of potential problems if they arise?
I completely understand that this is a high quality problem given my current NED status, and I very much want to keep that status; hence the reluctance to terminate Pembro early. I still think PV-10 did all of the heavy lifting but if I have Mel cells floating around and the Pembro is keeping them in check, I better keep on keeping on!